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Table of Contents

• Introduction

• Product Information

• Positives (Scientific Context)

• History

• Comparison With Related Stimulants

• Science Background

• Chemical Composition

• Sales to Licensed Companies

• Wholesale Framework

• Positive Uses in Research

• Legality

• FAQ

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Buy 4-Mar Online. 4-MAR Research Compound, also known as 4-Methylaminorex, is a synthetic psychostimulant historically investigated for appetite suppression and CNS stimulation. Today, it is used only as a forensic and analytical reference compound by licensed institutions.

Product Information

• Common Name: 4-MAR

• Chemical Name: 4-Methylaminorex

• Compound Class: Oxazoline-based stimulant

• Research Category: Controlled psychostimulant reference

• Primary Use: Forensic, toxicology, stimulant SAR studies

Positives (Scientific Context)

Within regulated environments, 4-MAR contributes positively by:

• Acting as a reference standard in stimulant identification

• Supporting historical stimulant research comparisons

• Enhancing toxicology screening accuracy

• Improving mass-spectral libraries

• Assisting regulatory and public-health research

These positives are strictly scientific, not therapeutic.

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History

4-Methylaminorex was first synthesized in the 1960s during pharmaceutical research into appetite suppressants. Initial animal studies showed potent stimulant effects, which ultimately led to abandonment of clinical development. Buy 4-Mar Online

In later decades, 4-MAR appeared in illicit stimulant markets, resulting in:

• International scheduling

• Inclusion in forensic drug panels

• Ongoing interest as a historical stimulant reference

Comparison With Related Stimulants

This comparison assists laboratories in accurate stimulant differentiation.

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Science Background

4-MAR functions primarily as:

• A dopamine and norepinephrine releasing agent

• A central nervous system stimulant

Its rigid oxazoline ring contributes to:

• High monoamine release

• Extended stimulant duration

• Increased toxicity risk

These properties make it valuable in stimulant SAR research.

Chemical Composition

• Molecular Formula: C₉H₁₂N₂O

• Molecular Weight: 164.2 g/mol

• Core Structure: Oxazoline ring

• Functional Groups: Amino, methyl substituent

Its structure is distinct from amphetamines, aiding forensic identification.

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Provision of 4-MAR Research Compound is restricted to:

• Government forensic laboratories

• Licensed academic institutions

• Authorized toxicology research centers

Requirements typically include:

• Controlled-substance license

• End-use declaration

• Secure storage compliance

Wholesale Framework

Bulk quantities are supplied only to:

• Government agencies

• GMP-compliant laboratories

• Institutional research programs

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Positive Uses in Research

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4-MAR supports:

• Historical stimulant trend analysis

• Forensic case confirmation

• CNS stimulant toxicity studies

• Regulatory reference development

• Analytical method validation

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Legality

• United States: Schedule I

• United Kingdom: Class A

• European Union: Controlled

• International: UN-monitored stimulant

Handling requires explicit regulatory approval.

Outbound DoFollow Resources:

• PubChem Compound Database

• UNODC Drug Monitoring Programme

Frequently Asked Questions

What is 4-MAR?
A synthetic stimulant used as a research reference compound.

Is 4-MAR approved for medical use?
No.

Can 4-MAR be used in research?
Yes, by licensed institutions only.

Why is 4-MAR controlled?
Due to high stimulant potency and toxicity.

Is 4-MAR safe to handle?
Only in regulated laboratory environments.

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4 Mar Online (4-Methylaminorex – 4-MAR) or 4-MAX is a stimulant drug of the 2-amino-5-aryloxazoline class that was first synthesized in 1960 by McNeil Laboratories. It is also known by its street names “U4Euh” (“Euphoria”) and “Ice”.  4_methylaminorex, Order 4 mar Online, 4 mar crystal for sale, Buy 4-mar online, where to buy 4 mar, 4 methylaminorex for sale

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The results of animal experiments conducted with this drug suggest that it has an abuse liability similar to cocaine and amphetamine. One study found that, “stimulus properties of racemic cis, racemic trans, and all four individual optical isomers of 4-methylaminorex were examined in rats trained to discriminate 1 mg/kg of S(+)amphetamine sulfate from saline.

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The S(+)amphetamine stimulus generalized to all of the agents investigated”. A second study in which rats trained to discriminate either 0.75 mg/kg S(+)-amphetamine or 1.5 mg/kg fenfluramine from saline generalized to aminorex as amphetamine stimulus but not to fenfluramine.

Rats trained to discriminate 8 mg/kg cocaine from saline generalized 4-methylaminorex to cocaine-stimulus. The reinforcing effects of cis-4-methylaminorex were determined in two models of intravenous drug self-administration in primates. Vehicle or 4-methylaminorex doses were substituted for cocaine. One of the two different doses of 4-methylaminorex maintained self-administration behavior above vehicle control levels.

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Dosage
4-methylaminorex can be smoked, insufflated or taken orally.

As an anorectic, the ED50 is 8.8 mg/kg in rats for the (±)-cis isomers. The (±)-trans isomers are slightly more potent at 7.0 mg/kg.  As a recreational drug, the effective dosage ranges from 5 to 25 mg.

In the 1970s McNeil Laboratories, Inc. was trying to bring 4-methylaminorex to drug market as a sympathomimetic (most commonly used as asthma-medicines), research name was McN-822, they mention that human dose would have been 0.25 mg/kg of body weight. They mention also LD50: 17 mg/kg for mice.

There is a patent about the use of 4-methylaminorex “as a nasal decongestant which, when administered orally, does not produce adverse central nervous system stimulant effects as experienced with other decongestants and anorexiants.” Dose mentioned is 0.25 mg/kg of body weight.

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