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Xylazine hydrochloride is a non-narcotic compound commonly used as a sedative, analgesic, and muscle relaxant. Xylazine has long been used in surgical procedures in small animal practice, but it is also used in large and wild animals. In veterinary anesthesia, xylazine is often used in combination with ketamine. Xylazine Hydrochloride for sale, buy Xylazine Hydrochloride, buy Xylazine Injection, Xylazine Injection for sale, where to buy Xylazine Injection
The sedative and analgesic effects of xylazine are associated with central nervous system depression. It induces muscle relaxation based on inhibition of the intraneural transmission of impulses in the central nervous system. 1 The degree of CNS inhibition is such that xylazine dose-dependently induces deep muscle relaxation and respiratory depression without interfering with more important functions of the nervous system. For general pharmacology:
The sleep-like state, whose depth is dose-dependent, usually lasts 1-2 hours, while the analgesia lasts 15-30 minutes. Its centrally acting muscle relaxant effect relaxes skeletal muscles and complements sedation and analgesia.
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In horses and deer, under the influence of xylazine, the respiratory rate is reduced, similar to that during natural sleep. After treatment with xylazine, there may be a decrease in heart rate and transient changes in myocardial conductivity, which is reflected in partial atrioventricular block. This is similar to atrioventricular block, which is common in normal horses. 2
As a tranquilizer for horses, xylazine hydrochloride is provided in injectable form, typically in 50 mL multidose vials or 100 mL multidose vials. Xylazine is available in various concentrations to suit both small and large animal applications. The pH is usually adjusted with citric acid and sodium (sodium citrate or sodium citrate dihydrate).
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The terminal half-life of xylazine was short in all species, suggesting that xylazine concentrations declined to undetectable levels within hours. Whole-body clearance varied greatly, being fastest in sheep and dogs and slowest in horses. Xylazine clearance is believed to be primarily due to metabolic clearance. Thus, there appear to be species-specific differences in drug metabolic rates.
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The amount of distribution was high in all species, apparently due to the lipophilic nature of the compound. 3
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Pharmacokinetic parameters after IM administration are shown in Table 2. There was no difference in half-life after IM and IV administration. Tmax values were reached within 15 minutes after drug administration and peak concentrations were very low. Due to the low concentration of drug in bovine plasma, it was not possible to determine pharmacokinetic parameters after intramuscular administration in cattle. 3
Table 2. Key pharmacokinetic parameters following intramuscular administration of 0.6, 0.2, 1.0, and 1.4 mg/kg of xylazine in horses, cattle, sheep and dogs, respectively.
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Degradation of xylazine tissue and milk residues
Two studies on radiolabeled xylazine were performed by researchers in 1975 and 1978. A study in which 4 animals (2 steers, 1 bull and 1 dairy cow) were given intramuscular 14C-labeled xylazine
